Complaint: 67-year-old female patient with decreased vision and metamorphopsia in the right eye.
Treatment: 3 Eylea intravitreal loadings were performed at 1 month intervals. There was no regression in
CNV. Magnovision iontophoresis was performed immediately after intravitreal Eylea injection from the 4th
dose onwards. The CNV regressed rapidly.
In cases resistant to or poorly responsive to intravitreal AntiVEGF, the application of Magnovision
immediately after intravitreal AntiVEGF injection increases drug concentrations at the subretinal level by
the iontophoresis effect. In our clinical practice, we routinely apply Magnovision after intravitreal AntiVEGF
and have observed a significant increase in treatment responses and a significant decrease in recurrences.
Our clinical research on this subject is ongoing.
Senile Macular Degeneration:
MAGNOVISION™ and Subtenon Bevacizumab + Platelet Rich Plasma Injection.


Complaint: A 77-year-old female patient has been followed up for 12 years with a diagnosis of age-related
macular degeneration. No AntiVEGF injections have been applied to the eyes. The vision in the left eye is at
the level of hand movements from 1 meter due to extensive geographic atrophy. Vision in the right eye is
0.2, and there is a small ellipsoid zone island in the middle of the geographic atrophy area.
Treatment: 3 Allogeneic PRP + Erythropoietin + Magnovision were applied at 1 month intervals. Vision
increased from 0.2 to 0.4, capillary perfusion of the geographic atrophy area increased and an increase in
photoreceptor functions was observed in pattern ERG. The patient was followed up for 1 booster dose of
PRP + Erythropoietin + Magnovision at 4-6 month intervals.

PRP should be prepared allogenically by collecting a total of 8 ml of venous blood from the arm into a
sterile citrated PRP tube. After centrifuging at +4°C and 2500 rpm for 8 minutes, the lower 1/3 of the plasma
in the tube is drawn into a 2.5 ml syringe and a total of 1 ml of PRP is obtained. Then, 0.5 ml of
erythropoietin is added to the same syringe (For Non Exudative AMD). A total of 1.5 ml of the solution of the
citrate, exosomes and erythropoietin mixture is injected into the subtenon space. This process is repeated
for 3 sessions in 2 months between 1 month interval. Platelet-rich plasma (PRP) containing neurotrophins
neurotrophic growth factors to increase the neural methabolism and reactivating the dormant
photoreceptors. Erithropoietin increase the neuroal capillary density and blood flow. Electromagnetic
iontophoresis (MagnoVisionTM) is essential for growth factors and molecules injected into the sub-tenon
space to pass into the sub-retinal space. MagnoVision also facilitates the passage of these systemic drug
molecules across the blood retina barrier. Omega3 (DHA and EPA) are essential for the phospholipid
structure of photoreceptor membranes. Lutein is the pigment required for the metabolism of rod cells.
Zeoxanthine is the pigment required for the metabolism of cone cells. Coenzyme Q ensures the removal of
drusens from the microenvironment through autophagy and ensures hemostasis. Exosome levels in
peripheral blood decrease with age. Therefore, PRP should be obtained allogeneically from a young healthy
donor.


WJ-MSC: a source of allogenic growth factors and neurotrophins.
NON EXUDATIVE AGE-RELATED MACULAR
DEGENERATION,
After Wharton jelly derived mesenchymal stem cell (WJ-MSC) and Magnovision application, the drusenoid
pigment epithelium detachment (PED) got lost without atrophy.
Magnovision electromagnetic stimulation device stimulates the WJ-MSCs in the subtenon space.
Magnovision increases exosom degranulation of WJ-MSCs. Exosomes contain growth factors and
neurotrophins. Electromagnetic iontophoresis is mandatory for the transport of growth factors and
neurotrophins from the scleral pores to the choroidal matrix and then to the subretinal region by tyrosin
kinase receptors.
MAGNOVISION™: electromagnetic iontophoresis and stimulation device. After the WJ-MSC injection, the
patient received a total of 10 sessions of Magnovision, 1 session per day. Then, 1 session of Magnovision was
applied every 4 months.

Tıbbi firmamız, halihazırda tedavisi bulunmayan bazı retina ve optik sinir
hastalıklarına çözüm sunmak amacıyla oftalmolojik tedavi cihazlarının
üretimi üzerinde çalışmaktadır.
Contact
info@bioretina.com.tr
+90 (312) 235 85 10
+90 (530) 321 75 90
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